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Background: Anxiety and depression are mental health problems that result in reduced health-related quality of life (HRQL), and increased mortality. Patients with COPD have a higher risk of anxiety and depression compared to healthy individuals. Recent studies reported a significant relationship between the presence of anxiety and depression and the functional status of COPD patients.Objectives: To study the effect of treatment of anxiety and depression on the physiological status in COPD patients.Materials and methods: The study included 50 severe COPD patients with depression and/or anxiety as evaluated and scored by Montgomery and Asberg Depression Rating Scale (MADRS) and Hamilton Anxiety Rating (HAM-A) Scale. They were classified into 2 groups: group I included 25 patients who received antidepressant/anxiolytic therapy in addition to COPD treatment and group II included 25 patients who received COPD treatment only. Modified Borg scale dyspnea score, spirometry (vital capacity, forced vital capacity, forced expiratory volume in first second and forced expiratory flow through 25-75% of expiration), arterial blood, MADRS and HAM-A scale were assessed in all patients at the start of the study and after 3 months.Results: Patients with severe COPD who were treated for depression and/or anxiety showed a significant improvement in MADRS, HAM-A and dyspnea scales, spirometeric parameters and oxygenation. MADRS and HAM-A scale showed a significant negative correlation to FEV1.

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Non-invasive ventilation (NIV) is the provision of ventilatory support to the lungs without the use of an endotracheal airway. It has emerged as an important tool in the treatment of diverse forms of acute respiratory failure. It not only reduces the need for invasive mechanical ventilation and its associated complications, but also reduces the complications associated with stay in the intensive care unit, length of hospital stay, and mortality in selected patients. This descriptive study was conducted on 50 critically ill patients with acute respiratory failure. All patients were subjected to full history taking, complete physical examination, chest and cardiac imaging and laboratory investigations.

Introduction:Covid-19 presents with a wide spectrum of illness, ranging from asymptomatic to critical disease and multi-organ dysfunction.Objectives: Detection and following up early and remote complications and cause of mortality in severe and critically ill COVID-19 patients post their ICU discharge.Patients and methods: Informed written consent, full clinical history and examination, full labs including d-dimer level and different body imaging according to patient clinical situation (ECG, echo, vascular duplex, CT chest, CT brain, MRI brain, abdominal ultrasonography.…) Results: COVID-19 is a systemic disease affecting multiple systems e.g. respiratory, cardiovascular, gastrointestinal, neuropsychiatric, haematological, and endocrinal systems leading to chronic critical illness and multi-organ failure with high mortality post ICU discharge. Conclusion:Severe and critical COVID-19 with prolonged ICU stay considered as a multi-organ disease affecting both functional and biological status which need close follow-up of COVID-19 survivors from their families and their health care team for early screening and adequate treatment of fatal complications with physical and mental rehabilitation.