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Objective The distribution of JC virus DNAin peripheral blood was surveyed by the polymerase chain reaction using the late genes as markers. Results Six out of 52 cases of hematological diseases and one systemic lupus erythematosus case out of 17 cases were positive for JCV DNA.After separation into B and T lymphocytes by a cell sorter, JCV DNAwas found in both cell types prepared from adult T cell leukemia and PMLpatients. Conclusion Only 1 or 2 copies of JCVgenome were calculated to exist in a cell based on the time course analysis of PCR. Only B lymphocytes and glial brain cells are knownto produce nuclear factors which support the growth of the virus. The result that B lymphocytes contained a copy number of JCVgenomesimilar to T lymphocytes suggests that there is some barrier to viral growth in susceptible B lymphocytes, and that the growth of JCV is different from that of other virulent viruses. (Internal Medicine 38: 932-937, 1999)

Drug-induced pneumonitis is a serious and an unpredictable side effect of chemotherapy in patients with malignant lymphoma. We present the case of a 51-year-old man who developed drug-induced pneumonitis during chemotherapy for non-Hodgkin's lymphoma in which pneumonitis was detected earlier by 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) than by high-resolution computed tomography (HRCT). After five courses of chemotherapy, 18F-FDG-PET was performed for assessing residual lesions, and diffuse lung uptake was incidentally observed. No symptoms were present, and HRCT performed immediately following PET revealed no abnormalities. Mild dyspnea appeared 3 days after PET, and additional HRCT revealed patchy ground-glass opacities disseminated with the appearance of interlobular septum thickening. Drug-induced pneumonitis was finally diagnosed, and treatment was initiated. 18F-FDG-PET can be an imaging modality for detecting drug-induced pneumonitis at an extremely early stage in which HRCT is incapable of revealing any abnormal changes.

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