Epidemiological studies in the last ten years have provided that nephrolithiasis is a risk factor for development of hypertension and have higher prevalence of diabetes mellitus and some hypertensive and diabetic patients are at greater risk for stone formation in connecting with altered calcium homeostasis; likewise in these last ten years, the deficit of zinc in the serum has been associated with the diabetes mellitus and another illnesses as: hipogonodism, Cushing Syndrome, celiac illness, and renal inadequacy, that propitiate to any age the osteoporosis appearance. It was used the creative idea as analysis method of data, applying the comparison by analogy between the well-known alterations of the homeostasis of the calcium and of the zinc, and those that can take place for the interaction among them. Review the data from the selected literature by this way, shows that, as conclusions: The event idiopathic calcium oxalate nephrolithiasis it is concomitant with the idiopathic hypercalciuria; the oxidative stress may be identifying by the presence of a direct correlation in the urine between the increments of calcium (hypercalciuria) and of zinc (hyperzincuria); the presence of idiopathic hypercalciuria it may be constitutes a precocious marker of the osteoporosis.