Background: Antimicrobial resistance is increasing worldwide, previous hospitalizations and use of antibiotics are well known risks factors for the development of urinary tract infections causedby gram-negative beta-lactamase producing bacteria, however, we know little about this problem during pregnancy.Objective: To determine the risk factors for the development of urinary tract infections caused by extended spectrum beta lactamase producing gram-negative bacteria during pregnancy. Methods:A case-control study was performed in 336 pregnant women with urinary tract infections caused by extended spectrum beta lactamase (ESBL) producing gram-negative bacteria and alsonon-producing extended spectrum beta lactamase gram-negative bacteria treated at the Women's Hospital in Culiacan, Mexico, between February 2019 and January 2020. Logistic regression was used to calculate odds ratio (OR) and 95% confidence intervals (95% CI). Results:The risk factors were recurrent urinary infection (OR = 1.84; 95% CI: 1.01, 3.34), Ceftriaxone administration (OR = 2.10; 95% CI: 1.01, 4.39), previous hospitalizations (OR = 4.03; 95% CI: 2.04, 7.93). Conclusion:The risk factors for urinary tract infections caused by extended spectrum beta lactamase producing gram-negative bacteria during pregnancy were previous hospitalizations, administration of ceftriaxone, and recurrent urinary tract infections.