Erosive and ulcerative lesions of the gastroduodenal zone in military personnel occupy one of the key places in the structure of the general pathology of internal organs. They significantly reduce the quality of life, affect the work capacity and personal life. Risk factors for their development is H. pylori infection, stress, severe trauma, certain drugs, and smoking. Delay in diagnosis and treatment can have negative consequences. The objective: to analyze the disease course, determine the clinical and pharmacoeconomic efficacy of the combined bismuth-containing and acid-suppressive treatment regimens for erosive gastroduodenal lesions in military personnel. Materials and methods. The study was designed as analyze of 40 medical charts of military personnel, who underwent treatment of the non-HP-associated erosive lesions of the gastroduodenal zone at the National Military Medical Clinical Center (NMMCC) «Main Military Clinical Hospital». The study used clinical, bibliographic, statistical, pharmacoeconomic analysis together with the assessment of the quality of life by SF-36 questionnaire. Results. It was found that the treatment regimen with use of rabeprazole and colloidal bismuth subcitrate has better clinical effectiveness (85% of patients recovered in 14 days of treatment compared to the group with omeprazole monotherapy, where the same indicator was 60%). Also, this scheme has a higher cost-utility (by 48%) and cost efficiency (by 56%) at a lower cost of treatment (by 17%). Conclusion. The treatment regimen for non-HP-associated erosive lesions of the gastroduodenal zone based on rabeprazole and colloidal bismuth subcitrate is more expedient from the point of view of clinical effectiveness and pharmacoeconomic feasibility compared to the regimen based on omeprazole alone and its use can improve the pharmacoeconomic results and rationality of budget funds use.