Background: Patients' demographics, presenting clinical and histopathological features for colo-rectal cancer (CRC) are important factors for patients' outcome and disease prognosis. This study aimed to describe the pattern of CRC in terms of patients' demographics, main presenting symptoms and histopathological features in Al Hassa region of Saudi Arabia. Subjects and Methods: A retrospective hospital records-based study which included reviewing of patients' records diagnosed with CRC at three general hospitals in Al Hassa region, Saudi Arabia. A compilation form was designed to collect information regarding socio-demographics, age at diagnosis; referral sites and the main presentations at CRC diagnosis. sites and the main presentations at CRC diagnosis. Histopathological reports were reviewed to delineate the main cytopathologic features, prominent cytological characteristics, the presence of predisposing pathology, and disease stage. Results: Of the 142 cases with CRC, 15.5% and 33.1% were affected before 40 and 50 years of age respectively. Emergency rooms were main referral sites for CRC cases (31.0%). Right colon was affected in 16.9% while left colonic lesions accounted for 62.7%. Intestinal obstruction was the main presentations (41.5%), and 26.1% presented with symptoms indicating distant metastastic lesions. Adenocarcinoma was the predominant pathological lesions (86.6%). Metastastic CRC was diagnosed in 62.7%. Duke's staging showed that 22.5% and 40.1% of lesions were classified into C and D categories respectively. Conclusion: Saudi patients with CRC present late with distant metastasis, and advanced disease stage. A sizeable proportion of patients developed the lesions at relatively young age. Screening recommendations should be enacted and revised in response to current change with younger age of affection.

Aims: This study explores the cumulative effects of cardiovascular risk factors on the health-related quality of life (HRQL) among the elderly. Study Design: Our study comprises a cross-sectional design. Place and Duration of Study: The Nov 2021 population-based research represents the Saudi Eastern Province population aged 60 years and above. Methodology: Information was collected through home-based personal interviews using a structured questionnaire on the participants' health. The participants provided informed verbal consent. On each scale of the SF-36 questionnaire, multiple linear regression examined the relationships between obesity, hypertension, diabetes and HRQL after adjusting for sociodemographic data and lifestyle factors. Results: Diabetes and hypertension registered the worst HRQL among males on all the scales (‒53.8 to ‒22.0 points according to the scale) in the two-factor cluster and male clusters except social functioning and role-emotional. Obesity and diabetes registered the worst HRQL on all the scales (–24.4 to –40.4 points according to the scale) in the two-factor female cluster except physical functioning, bodily pain and general health, and on all scales in female clusters except physical functioning, bodily pain, general health, social functioning and role-emotional. Conclusion: Our study shows that obesity, hypertension and diabetes (as separate factors and in combination) negatively affect HRQL.