Background:The discharge of improperly treated hospital landfill presents an enormous public health risk. In Burkina Faso, the management of hospital's wastewaters and the current antibiotic susceptibility of clinically relevant isolates need to be determined, because the multi-drug resistant isolates have been previously described in hospital settings. The aim of this study was to determine antibiotic resistance profile of isolates circulating in Ouagadougou. Methods: The biochemical characterization of the isolates was carried out by tests from the API 20E test and completed with molecular characterization by simple polyemerase chain reaction (PCR). Antibiotic susceptibility of the isolates was determined using the recommendations of CA-SFM 2019. Results: The hospital wastewaters do not undergo any treatment before been discharged into the environment. A total of 171 presumed isolates of Salmonella spp, Pseudomonas spp, and Escherichia coli were identified in this study. These isolates derived from environment (n=19) and clinical (n=152). These isolates were resistant to amoxicillin + clavulanic acid (95.32%), cefoxitin (72.51%), ceftazidime (78.94%), cefepime (80.71%), tobramycin (59.64%), gentamicin (42.10%), nalidixic acid (68.42%), norfloxacin (59.06%), ciprofloxacin (56.14%), imipenem (0.00%), chloramphenicol (26.31%), and colistin (77.77%). Somewhere else, 46 presumptive Staphylococcus aureus were resistant to vancomycin (30.43%), oxacillin (13.04%), penicillin G (89.13%), ceftriaxone (15.21%), cefoxitin (2.73%),t (36.95%), kanamycin (30.43%), ciprofloxacin (15.21%), norfloxacin (43.47%), Tetracycline (56.52%), chloramphenicol (13.04%), and Fosfomycin (2.73%). Conclusion: The hospital wastewaters harbour a variety of pathogens, most of which are resistant to several families of antibiotics.

Introduction: The poor quality of medicines represents a threat to public health. However, the causes come from a variety of factors such as the use of an active ingredient of insufficient quality, inadequate manufacturing processes, or even unsuitable packaging, insufficient quality control measures. Thus, this study aims to assess the quality of injectable ampicillin in the formal and informal circuit in the city of Yaoundé. Methodology: Thirty (30) batches of injectable ampicillin collected in the city of Yaoundé were the subject of an experimental study. The European and American Pharmacopoeia (USP) standards were used to assess pharmaco-technical and physicochemical compliance. Results: According to the parameters including respect for the mass, the pH, the labeling and the dosage of the active ingredient were found non-compliant on 02 batches (7%), 01 batch (3%), 25 batches (83% ) and 01 lot (3%). However, of the 30 batches analyzed, 53% were non-compliant, including 13%, 3%, and 37% respectively from the private, public and informal sectors. Conclusion: More than half of the batches of ampicillin injection analyzed in this study had corrupted qualities. Strict measures are necessary on the quality of badly needed drugs such as ampicillin from the first people in charge of drug control in the city of Yaoundé in order to improve the quality of treatment for pathologies.

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