HighlightsRCC is the predominant primary tumor for isolated pancreatic metastases.Pancreatic metastases from RCC generally tends to slow growth and indolent behavior.Surgical resection may be curative and should be considered in selected patients.It is still controversial whether to perform typical or atypical surgical procedures.Pancreatic metastasis after a prolonged period may imply change in tumor biology.

Non melanoma skin cancer is one of the most frequent malignant tumors among humans. A non-invasive technique, with high sensitivity and high specificity, would be the most suitable method for basal cell carcinoma (BCC) or other malignancies diagnostics, instead of the well established biopsy and histopathology examination. In the last decades, a non-invasive, spectroscopic diagnostic method was introduced, the laser induced fluorescence (LIF), which could generate an image contrast between different states of skin tissue. The noninvasiveness consists in that this biophotonic method do not require tissue sample excision, what is necessary in histopathology characterization and biochemical analysis of the skin tissue samples, which is worldwide used as an evaluation gold standard.The object of this study is to establish the possibilities of a relatively portable system for laser induced skin autofluorescence to differentiate malignant from nonmalignant skin lesions. Unstained human skin samples, excised from humans undergoing biopsy examination, were irradiated with a Nd:YAG-3ω laser (λ=355 nm, 6 ns), used as an excitation source for the autofluorescence measurements. A portable fiber-based spectrometer was used to record fluorescence spectra of the sites of interest.The ex vivo results, obtained with this spectroscopic technique, were correlated with the histopathology results. After the analysis of the fluorescence spectra of almost 60 skin tissue areas, we developed an algorithm to distinguish different types of malignant lesions, including inflammatory areas. Optimization of the data analysis and potential use of LIF spectroscopy with 355 nm Nd:YAG laser excitation of tissue autofluorescence for clinical applications are discussed.

Aim: The aim of this study was to investigate the expression of CXCL12, CXCR4and of VEGFR-3 in primary urothelial bladder carcinoma(UCs) and their recurrentin relation to grade and pT status.Material and Method: Immunohistochemistry was applied on 67 primary tumorsand their 67 recurrences.Results: The expression of CXCL12 both in primary cancer(PC) and in recurrentcancer (RC)was positively associated to grade(p<0.0001 and p<0.0001respectively) and pT stage (p=0.001 and p=0.007 respectively).The expression ofCXCR4 both in PC and RC was positively related to grade (p=0.001 and p<0.0001respectively) and pT stage (p=0.008 and p=0.005 respectively).We compared theexpression of CXCL12 and CXCR4 in PC related to RC and we found that both ofthem are more intensive in RC than in PC (p<0.0001 and p<0.0001respectively).CXCL12 was positively correlated with the expression of VEGFR3in RC (p=0.045).Conclusions: CXCL12 and CXCR4 expression was related toadverse prognostic markers at UCs through their association with grade and pTstage both in PC and RC. The axis CXCL12 /CXCR4 may influence the expressionof VEGFR3 in UCs and promote tumour recurrence