BackgroundPregnancy-Induced Hypertension (PIH) is a universal problem and its global incidence is estimated between 5-14% of all pregnancies [1,2]. It is one of the major causes of pregnancy-related maternal deaths in the United States [3]. In Ghana, PIH contributes 40% of all maternal deaths [4] and one of the commonest pregnancy related complication encountered in Ghanaian hospitals.Pregnancy-Induced Hypertension is the main cause of renal impairment especially acute kidney injury in late pregnancy, with reported incidence of between 2% and 11.3% in preeclampsia and eclampsia patients [5,6]. Chronic kidney disease (CKD) is a common complication of hypertensive patients in Ghana, with a prevalence ranging between 22%-46.9% among the general population [7,8]. Kidney disease and preeclampsia however, are caused by similar factors; both disorders have been linked to hypertension, obesity, insulin resistance and endothelial dysfunction [9][10][11][12][13][14][15].A strong correlation exists between the incidence of preeclampsia and later incidence of kidney disease; moreover, preeclampsia further increases the risk for developing End-Stage Renal Disease (ESRD) [16]. Screening for renal impairment in pregnant women is not performed routinely during antenatal visits as such there is scanty information on this condition in these categories of women.Renal equations have been widely accepted for use in the general population to offset the challenges associated with the use of the collection of 24-hour urine for the calculation of creatinine clearance.However, the use of these equations in pregnant women still requires validation from large sample size and across different populations.This study thus, assessed renal function in women presenting with hypertensive pregnancy using renal equations, which eliminates the cumbersome nature of requesting for 24-hour urine, with the aim of providing preliminary data that could influence the early diagnosis and management of CKD in women presenting with hypertensive pregnancy in Ghana and to encourage the adoption of these equations for routine renal assessment in women with hypertensive pregnancy. Materials and Methods Study design and settingThis Hospital-based case-control study was conducted at the Abstract Background: Pregnant women with hypertension are at an increased risk of renal impairment. This study assessed the use of CKD-EPI and 4v-MDRD for early diagnosis of renal impairment in pregnant women with hypertension.