This study examined the extent to which livestock production has contributed to food security of the rural households in Southwestern Nigeria. Multistage sampling procedure was used to select respondents for the study. Fifty percent of the states in Southwestern Nigeria and 30% of rural households in the selected local government areas were randomly selected resulting in a sample size of 306 respondents. Household food insecurity access scale (HFIAS), food insecurity scale was used to assess the food insecurity of the respondents. Data were analyzed using descriptive statistics while binomial regression was used to determine the determinants of food security at p = 0.05. Most respondents (76.1%) were males and married (83.7%), while about half (46.0%) of them completed secondary education. Mean age, household size and monthly income from livestock enterprises were 48.8 ± 12.8 years, 6.6 ± 3.2 and N45,068 ± 97,077, respectively. A large proportion (71.9%) practiced extensive system of livestock production. Sources of information (β = 5.304), income (β = 7.453) and constraints to livestock enterprises (β = 2.807) increased the odds of their food security. Policies that encouraged that promote diversification of income sources should be promoted to increase entrepreneurs' income in order to improve food security situation of rural households.