The item presents the results of a comparative immune enzymometric assay of the matrix metalloproteinases (MMP-1, MMP-2, MMP-8, MMP-9) and tissue inhibitors (TIMP-1, TIMP-2) levels in blood serum, oral fluid of children belonging to Health Groups I and II and children with type 1 diabetes mellitus (disease course within the range of 1 to 10 years) in projection onto the level of hygiene and the periodontal status. The role of MMP-2, MMP-8, MMP-9 in the pathogenetic mechanisms of inflammatory periodontal diseases development has been identified. Children with a short experience of endocrinopathy were found to have a balanced synthesis of matrix metalloproteinases and their tissue inhibitors in case of reversible inflammatory alterations in periodontal tissues. Children with a longer disease course were found to feature an imbalance between matrix metalloproteinases and tissue inhibitors, which provokes disturbances in remodeling and structural organization of the extracellular matrix in periodontal tissues, along with the development of inflammatory destructive issues. K E Y w O R D S-child population, type 1 diabetes mellitus, periodontal issues, matrix metalloproteinases, tissue inhibitors, oral fluid, blood serum

Diabetes mellitus is one of the most serious issues faced nowadays both by medicine and society in general, which is due to the wide spread of endocrine issues affecting nearly every country globally, the growing incidence rate, as well as the severity of complications that are hard to treat. Type 2 diabetes mellitus increases significantly the risk of developing acute cerebral blood circulation disorders, which urges further comprehensive studies focusing on the role played by the vascular-platelet relation and coagulation hemostasis in the development and progression of diabetic vascular complications. The results of our study, which involved 74 patients with acute cerebral circulation disorders against type 2 diabetes mellitus revealed alterations affecting the hemostasis system. This could be seen from activated vascular-platelet and coagulation links, decreased anticoagulant activity, and a slowdown in fibrinolysis. The severity of disorders induced by the alterations in the hemorheological profile and the microcirculatory hemostasis are associated with the duration of type 2 diabetes mellitus and the carbohydrate metabolism indicators (hyperglycemia, increased HbA1c levels and glycation end products).

Acute viral respiratory infections add to the progression risk of the already existing pathologies, including those of cardiovascular origin. Life-threatening complications emerging against SARS-CoV-2 (severe acute respiratory syndrome), which causes COVID-19 (Coronavirus disease 2019), explain the need to study the cardiovascular effects of COVID-19 in order to offer rational medical care to patients belonging to various age categories. This article presents a comprehensive assessment of changes affecting the main hemostasis parameters in patients with acute cerebral circulatory disorders against the SARS-CoV-2 virus infection. There is special attention paid to the pathophysiological features occurring against the infectious process involving the hemostasis system. Our data shows that the differences in the main hemostatic parameters in patients with acute cerebral circulatory disorders occurring against the SARS-CoV-2 virus infection are due to the degree of the body responsiveness and the severity of the comorbid pathology. Reducing the risk of adverse conditions developing in this category of patients is possible in case of responsible monitoring focusing on the main indicators of the cardiovascular system status, as well as provided there are advanced approaches introduced in order to prevent and treat thrombotic/thromboembolic complications.

CardiovasCular adaptations of foreign students to ClimatiC and geographiCal Conditions of stavropol regiona b s t r a c t -Purpose of research: studying adaptive opportunities of the cardiovascular system of foreign students to the climatic and geographical conditions of Stavropol region. Methods: The data sample included the Stavropol and foreign students, natives of the countries of the Southern Asia, the Western Asia and Africa in the youthful period of ontogenesis and the first period of a maturity. In total 218 students, from them the Russian students were examined: youths -73 persons, men -55 people; foreign students: youths -36 people, men -54 persons. Results: Stable and compensatory adaptive reactions are characteristic to youths and men from the Southern Asia and to men from the Western Asia. A condition of the critical tension (excessive tension) are characteristic to firstyear students and senior students from Africa. Findings: It is established that the greatest stress of adaptation mechanisms is experienced by students from Africa. K E y w o r d s -adaptation, mathematical analysis of the heart rhythm, variational pulsometry, foreign students, Stavropol region.

presents findings of the research investigating the effect of various glucose concentrations on the morphometric parameters of red blood cells. The principal component method was employed in order to determine the most significant indicators in the experiment. The experiment was aimed to investigate the effect of hyperglycemia on the shape, size and functional parameters of erythrocytes depending on the glucose concentration and exposure time. It was established that characteristic changes in the shape and size of erythrocytes induced by hyperglycemia are correlative with concentration of glucose and exposure time.K E Y w O R D S -glucose concentration, red blood cells, morphometric parameters, principal component analysis.