The performance characteristics and physiological response of broiler chickens to oral supplementation with Telfairia occidentalis leaf extract (TOLE) at finisher stage were investigated. One hundred and twenty unsexed broilers of Arbor Acre strain at 28-day-old were randomly divided into four treatment groups of oral supplementation each with three replicates. The treatment groups are: T 1= Water (control), T 2 =Vitalyte, T 3 =15% TOLE, and T 4 =30% TOLE. The experiment lasted for 70 days, during which data collection was carried out and blood obtained for analysis at the 70 th day. Results revealed that average body weight gain, average daily feed intake, and feed conversion ratio were significantly (P<0.05) affected by oral TOLE while percentage crop and gizzard weight were not significantly (P>0.05) affected by oral TOLE. Measured blood parameters of the groups on TOLE were significantly (P<0.05) higher than those on vitalyte and control group. Hemoglobin concentration, packed cell volume and red blood cell counts revealed that broilers on oral TOLE had better values when compared to those on vitalyte and control. Meanwhile, white blood cell count was not affected significantly (P>0.05) by the oral supplementations. Apart from creatinine, uric acid and globulin, other serum metabolites investigated were significantly (P<0.05) affected by TOLE inclusions. No mortality was recorded during the experiment. Oral supplementation of TOLE compared well with conventional vitamin supplement based on measured parameters, 30% supplementation can be used as vitamin supplement in broiler chicken at finisher phase.