In Nigeria, doctors have the sole primary responsibility of prescribing medications for patients, contrarily, in the United Kingdom (UK), physiotherapists have advanced from being supplementary prescribers in 2005 to independent prescribers in 2012; and this was aimed at improving patient's accessibility to medications. The primary aim of this study was to investigate the opinion of Nigerian medical doctors on physiotherapists assuming the roles of supplementary prescribers. A self-administered questionnaire was used to seek opinion of 372 medical doctors in purposively selected hospitals. Descriptive statistics of frequency, percentages, mean, standard deviation and chi-square were used to analyze the data. Two hundred and twenty-two doctors (59.7%) were unaware that physiotherapists are supplementary prescribers in UK. The number of respondents (55.1%) who objected to physiotherapists becoming supplementary prescribers was significantly higher than those who supported it (X²-3.88, p = 0.05). Amongst to that supported supplementary (44.9%) prescription for physiotherapists, 98.2%, 72.5% and 58.7% opined that physiotherapists should be allowed prescribe analgesics, NSAIDs and muscle relaxants respectively. Only 4 doctors (1.1%) supported the prescription of anti-hypertensive drugs. We concluded that most medical doctors are unaware that physiotherapists as supplementary prescribers in UK and majority of them objected to Nigerian physiotherapists being recognized as supplementary prescribers.