Muhtemelen modafinil kullanımıyla ilişkili geç başlangıçlı mani: Bir olgu sunumu Modafinil gündüz uykululuğu ile giden çeşitli klinik durumların tedavisinde kullanılmaktadır. Modafinil ekleme tedavisinin aynı zamanda, unipolar ve bipolar depresyon ile şizofrenide görülen yorgunluk ve uykululuk gibi rezidüel belirtileri düzeltebileceği öne sürülmektedir. Bu ilacın psikoz ve mani oluşturma olasılığı ile ilgili bir durum söz konusu olmakla birlikte, bu konuya ilişkin çok az sayıda olgu bildirimi yayınlanmıştır. Bu yazıda, modafinil tedavisi sırasında gelişen psikotik özellikli geç başlangıçlı bir mani olgusu sunmaktayız. Hastanın psikiyatrik öyküsü ve klinik gidişi, maninin büyük olasılıkla modafinil kullanımıyla ilişkili olabileceğini düşündürmektedir ve bilgilerimize göre bu olgu literatürdeki modafinile bağlı olarak gelişen ilk geç başlangıçlı mani bildirisidir. Modafinil tedavisi alan hastaların dikkatli psikiyatrik izlemi gerektiğini önermekteyiz.
Aim:The aim of the present study was to determine dissatisfaction with body appearance and bodily functions and to assess self-esteem in somatizing patients. Methods:Body image and self-esteem were investigated in 128 women; 34 of those had diagnosed somatoform disorders, 50 were breast cancer patients with total mastectomy surgery alone, and 44 were healthy subjects. Body image and self-esteem were assessed using the Body Cathexis Scale and Rosenberg Self-Esteem Scale. Results:The two clinical groups did not differ from one another (z = -1.832, P = 0.067), but differed from healthy controls in terms of body image (somatizing patients vs healthy controls, z = -3.628, P < 0.001; total mastectomy patients vs healthy controls, z = -3.172, P = 0.002). They also did not differ significantly in terms of self-esteem (z = -0.936, P = 0.349) when depressive symptoms were controlled. No statistically significant difference was observed between total mastectomy patients and healthy controls in terms of self-esteem (z = -1.727, P = 0.084). The lower levels of self-esteem in somatizing patients were largely mediated by depressive symptoms. Depressed and non-depressed somatizing patients differed significantly from healthy controls with respect to their self-esteem and body image. Conclusions:Somatizing patients who were dissatisfied with their bodily functions and appearance had lower levels of self-esteem and high comorbidity of depression. In clinical practice it is suggested that clinicians should take into account psychiatric comorbidity, self-esteem, and body image in somatizing patients when planning treatment approaches.
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