The present study demonstrated that alpha2-macroglobulin blockade of matrix metalloproteinases can enhance bone-tendon healing. This effect of alpha2-macroglobulin could occur through its effect solely on collagenase or on a subset of matrix metalloproteinases that are present at the healing interface.

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AMAÇBu çalışmada, allogreft ya da otogreft ile ön çapraz bağ (ÖÇB) rekonstrüksiyonun klinik sonuçları araştırıldı. GEREÇ VE YÖNTEMAnterior tibial tendon (ATT) allogreft (n=52) ya da dörtlü hamstring (DHT) otogreft (n=30) ile ön çapraz bağ (ÖÇB) rekonstrüksiyonu uygulanan 82 hastanın sonuçları geriye dönük olarak değerlendirildi. Hastalar son kontrolde, Uluslararası Diz Dokümantasyon Komitesi'nin (IKDC) diz skoru ve Lysholm skoru, performans (tek bacak zıplama) ve laksite (pivot-shift, Lachman, öne çekmece) testleri ile değerlendirildi. BULGULARİki grup arasında yaş, cinsiyet dağılımı, ameliyat edilen taraf, ameliyat öncesi süre ve eşlik eden yaralanmalar açısın-dan farklılık yoktu (p>0,05). IKDC, Lysholm, performans ve laksite bakımndan her iki grupta da sonuçlar tatmin ediciydi ancak gruplar arasında anlamlı fark yoktu (p>0,05). Fakat, ATT allogreft grubunda DHT otogreft grubuna göre daha fazla effüzyona rastlandı. SONUÇBu çalışmanın sonuçları ATT allogreft ya da DHT otogreft ile ÖÇB rekonstrüksiyonunun klinik sonuçlarının benzer olduğunu göstermektedir. Bununla birlikte allogreftlerde görülen immün yanıta çözümler geliştirilmesiyle ÖÇB rekonstrüksi-yonunda iyi bir greft alternatifi olabileceğini düşünüyoruz.Anahtar Sözcükler: Anterior tibial tendon allogreft; hamstring tendon otogreft; ön çapraz bağ yaralanması.

BackgroundAlthough, glucocorticoid (GC) and calcitonin-induced changes in bone repair have been studied previously, the exact effects of these on fracture healing remain controversial. Hence, the purpose of this experimental study is to determine biochemical and histological effects of locally administrated GC and systemically administrated calcitonin on the kinetics of healing response after bone marrow ablation in rats.MethodsAfter having undergone marrow ablation, a steroid-treated group of rats (n = 24) received a single dose of intramedullary methylprednisolone (2 mg/kg), a calcitonin-treated group (n = 24) received intermittently administrated subcutaneous salmon calcitonin (16 IU/kg), and a control group (n = 24) received intramedullary saline (25 μl).ResultsBlood samples taken on days 1, 3, 7, 9, and 15 after ablation showed an increase in serum calcium, alkaline phosphatase (ALP), and phosphate levels in the Calcitonin and Control groups. Levels of calcium and ALP peaked on day 7 after ablation. However, an increase in phosphate levels indicated a biphasic reaction that peaked on the third and ninth day after ablation. Hypercalcemia was not observed in Steroid group because of the inhibition of osteoclastic bone resorption. In that group, the serum levels of ALP and phosphate were lower than baseline levels. The levels of urinary calcium excretion peaked 3 to 7 days after marrow ablation in the control group and 7 to 9 days after that procedure in the steroid group. Histologic evaluation showed that the rats in the control group demonstrated the expected healing period according to the histological grades and that a delay in healing occurred in the calcitonin group after day 9 because of the inhibition of osteoclastic bone resorption. All rats in the steroid group exhibited a decrease and delayed healing response.ConclusionTotal serum calcium, phosphate, and ALP levels increased after bilateral tibial bone marrow ablation and urine calcium and hydroxyproline excretion also increased as a factor of bone resorption. Subcutaneously administrated salmon calcitonin did not affect biochemical changes after marrow ablation. Single-dose intramedullary methylprednisolone inhibited extra-tibial bone resorption induced by cytokines after bone marrow ablation.

SummaryBackgroundThe aim of this retrospective study is to determine our experience of technique success rate, complications and clinical results in long term follow up for computed tomography (CT)-guided radiofrequency ablation [RA] therapy for osteoid osteoma (OO).Material/MethodsWe performed RA therapy to 18 patients with OO referred to interventional radiology from other clinics primarily from orthopedics; between January 2011 to May 2014. Daytime and nighttime pain intensity of 18 patients was noted according to visual analog scale (VAS). After procedure pain intensity was compared with before one. We also discussed other factors can affect it.ResultsAll procedures were completed technically successful for all patients [100%]. We did not experience any major complication or mortality. However we had 3 minor complications. Pain came back in 1 patient after 5 months from procedure and it was considered as recurrence. Dramatic pain intensity fall was seen in patients after procedure, both daytime and nighttime. However we did not find and statistically significant change in comparison of pain intensity reduce and time needed to return back to routine life when using patients demographic data and lesion size.ConclusionsCT guided RA therapy of OO is minimally invasive, effective and secure procedure.