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Background/Aim: This study aimed to determine the role of the peroxisome proliferator-activated receptorgamma (PPARg) C161T genotype and allele frequencies in predisposition to colorectal cancer (CRC). Patients and Methods: PPARg C161T (His447His; rs3856806) gene polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism analysis in patients with CRC (n=101) and controls (n=238). Results: The T161 allele (CT+TT genotypes) of PPARg C161T polymorphism was associated with CRC development (p<0.001; OR=3.239,. Subgroup analysis showed that the T161 allele was associated with a 3.056-fold increased risk for colon cancer (CC) (p<0.001; 95%CI=1. 709-5.464) and 3.529-fold increased risk for rectal cancer (RC) (p<0.001;. Frequencies of the T161 allele were also higher in total CRC and CC patients with poorly differentiated tumors (p<0.001, c 2 =30,601, OR=3.109; Fisher exact test, respectively). Conclusion: PPARg T161 allele carriers have increased risk for developing CRC.

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