Purpose. To compare the macular and peripapillary choroidal thickness in eyes with pseudoexfoliation (PEX) syndrome and PEX glaucoma with the normal eyes of healthy controls. Materials and Methods. In this prospective study, 30 eyes of 30 patients with PEX syndrome, 28 eyes of 28 patients with PEX glaucoma, and 30 eyes of 30 age-matched healthy subjects were enrolled. Choroidal thicknesses in the macular and peripapillary areas were measured by using spectral domain optical coherence tomography. Results. Gender, age, and axial length did not significantly differ between the groups (all, p > 0.05). The mean values of choroidal thickness in the macular and peripapillary areas (except the superior quadrant) in the patients with PEX syndrome and PEX glaucoma were lower compared with controls (all p < 0.05). The mean values of the macular and peripapillary choroidal thickness in the PEX glaucoma group were lower compared with PEX syndrome group; however this difference was not significant. Conclusions. The findings of this study revealed that macular and peripapillary choroidal thicknesses were decreased in PEX syndrome and PEX glaucoma cases. The role of choroid in the development of glaucomatous damage in patients with PEX syndrome remains unclear.

ÖZETAmaç: Monitörize anestezi bakımında deksmedetomidin ile midazolam/remifentanil kombinasyonunun nazal septum cerrahisinde karşılaştırılması amaçlandı.Gereç ve Yöntem: Lokal anestezi altında nazal septum cerrahisi planlanan 50 hasta rasgele iki gruba ayrıldı. Grup D'ye 10 dk. Sonuç: Monitorize anestezi bakımında hızlı sedasyon istendiğinde, akciğer hastalığı yoksa desaturasyon açısından uygun önlemler alınarak midazolam/remifentanil kombinasyonu; semptomatik akciğer hastalığı olanlarda maliyeti göz önünde bulundurarak ve bradikardi açısından dikkatli olunarak deksmedetomidin tercih edilebilir.Anahtar kelimeler: Monitörize anestezi bakımı, deksmedetomidin, midazolam, remifentanil SUMMARY Comparison of Dexmedetomidine versus Midazolam/Remifentanil Combination for Monitorized Anaesthesia CareObjective: The aim of this study was to compare dexmedetomidine versus midazolam/remifentanil combination for monitorized anaesthesia care during nasal septal surgery.Material and Methods: 50 patients undergoing nasal septal surgery under local anaesthesia were randomly assigned into two groups. Group D received 0,3 µg kg -1 hr -1 dexmedetomidine infusion after the loading dose of 1 µg kg -1 /10 min. Group M/R received 0,05 mg kg -1 bolus dose of midazolam over 30 seconds followed by 0,05 mg kg -1 min -1 remifentanil infusion. The infusion rates were adjusted to target level of sedation and analgesia scores. Hemodynamic and respiratory parameters, analgesia and sedation scores were recorded before (0 min.) and 1, 5 and 10 minutes after sedation, and every 5 minutes thereafter. Total amount of drugs used, patient and surgeon satisfaction scores, hemodynamic and respiratory parameters, postanaesthetic Aldrete scores, amnesia and postoperative recovery scores and side effects were recorded at 1., 5., 15., 30. minutes, and 1., 2., and 4. hours, postoperatively.Results: Sedation scores were higher in group M/R at 5 and 15 minutes, postoperatively (p<0.05). Heart rates were lower in Group D at 10 and 35 minutes (p<0.05). Respiratory rates were lower in Group M/R throughout the operation (p<0.05) and also SpO 2 values were lower at 5., 10. and 15. minutes (p<0.05). Cost of anesthesia in Group D was higher (p<0.05).Conclusion: During monitorized anaesthesia care midazolam/remifentanil can be used for rapid onset of sedation in the absence of pulmonary disease while taking measures for desaturation. Dexmedetomidine may be preferred not disregarding bradycardic complications in symptomatic pulmonary disease, and its higher cost.

Otoacoustic emission test has been widely used in clinical trials since it was introduced by Kempt in 1978 for the first time. 1 It has been preferred in clinical trials due to being simple, cost-effective, non-invasive, and having ability to evaluate frequency specific outer hair cell functions objectively.