Zusammenfussung. Eine Totalsynthese des Hexahydroindolizin-Alkaloids Ipalbidin (7) und seines P-D-Glucosids Ipalbin (1) wird beschricben. Dcr zentrale Syntheseschritt besteht aus ciner N-Acylierung des vinylogen Amidsystems 3, gefolgt von einer internen Kondensation zum penta-

ChemInform Abstract Chorismate mutases catalyze the conversion of chorismic acid (I) to prephenic acid (II). In order to evaluate potential inhibitors of these enzymes, several bicyclic molecules such as (III) -(VIII) are synthesized which mimic the presumed transition state of the rearrangement. The endo-diacid (III) is the most potent inhibitor for a chorismate mutase, while the compounds (VII) and (VIII) have only poor inhibiting activity. Structure-activity relationships are discussed.

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Synthetic Strategies in Combinatorial Chemistry -(38 refs.). -(SPALLER, M. R.; BURGER, M. T.; FARDIS, M.; BARTLETT, P. A.; Curr.

Ein phosphorhaltiges Analoges von Statin wird hergestellt und in verschiedene Oligopeptide inkorporiert.