Climate change is currently one of the most important global environmental issues that negatively affect agriculture in Sub-Saharan Africa. This importance has resulted in a great interest to understand both the farmers' perception of and adaptation to observed climate change. A good number of previous studies did explicitly focus on several adaptation strategies. Nevertheless, a better understanding of the socio-economic drivers underlying specific adaptive measures to climate change is crucial to inform specific adaptation components that will fall into a wider adaptation plan. In this respect, the present study focuses on the use of multiple cropping systems consisting of growing two or more crops on the same field either at the same time or one after another as climate change adaptation strategy. Accordingly, this paper examines different strategies commonly used to intensify agricultural production in tropical agriculture. These include crop rotation and association in the center of Benin.Data were collected in central Benin through interviews with 80 farmers selected by using a multistage random sampling technique. Data analysis was carried-out by using descriptive statistics and a Probit regression. The results showed that the major drivers of multiple cropping systems as adaptive strategy to climate change include contacts with extension services, education level, and farm size. Major constraints to the use of multiple cropping systems are gender, adult literacy, perception of adaptation to climate change, experience with climate change impacts, and farmer location. Policy options should include, among others, production of information related to impacts of climate change and their dissemination through formal services such as extension services; identification of potential ways to greatly improve returns on extra agricultural activities, and investigating on the effects of past adoption strategies on the different cropping systems.