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Article InformationIn the present study, In vitro anticancer effects of Euphorbia hirta were investigated. The objectives of this study are to find the presence of secondary metabolites by preliminary phytochemical investigation and FTIR analysis in the Euphorbia hirta. Ethanolic leaf extract of Euphorbia hirta was tested for its cytotoxicity against Dalton Lymphoma Ascites (DLA) and Ehrlich Ascites Carcinoma (EAC) cell lines using preliminary screening technique (Trypan Blue method and standard MTT colorimetric method). The Euphorbia hirta leaf extract was found to be more cytotoxic against Ehrlich Ascites Carcinoma cell lines when compared to cytotoxic activity against Dalton Lymphoma Ascites cell lines where as 59.67% cytotoxicity were noticed against Ehrlich Ascites Carcinoma cell lines. Extract of Euphorbia hirta showed a dose-dependent reduction of proliferation and induction of apoptosis in the Carcinoma cell lines cells. Ethanolic leaf extract of Euphorbia hirta showed potent cytotoxic activity against DLA and EAC cell lines and its IC50 value was found to be 560.83μg/ml and 384.7 μg/ml of extract respectively. The in vitro outcomes of Euphorbia hirta extract showed potent anticancer effect against both DLA and EAC cell lines.