Background: Patients with subacute ankle sprain demonstrate pain with movement, significantly reduced range of motion of ankle joint and change in dynamic gait parameters. Objective: To determine the difference between the effectiveness of muscle energy technique (MET) and contract relax with mulligan's mobilization with movement (MWM) technique in the treatment of subacute stage of lateral ankle sprain. Methods: Forty patients (mean age=22.80±2.55 years, male: female 60%: 40%) were randomly allocated into two groups. Group A was treated with MET and mulligan's MWM technique, group B received contract relax and mulligan's MWM technique for 4 weeks (3 days per week). Results: Analysis with paired t test revealed significant reduction (p<0.05) in pain and significant improvement in range of motion of ankle joint and some gait variables within the group for both groups. However independent t test for comparing the pre, post and improvement from pre to post data between group A and group B showed no statistical significant difference (p>0.05). Conclusion: This study concluded that both MET and contract relax with mulligan's MWM are equally effective techniques to reduce pain, increase ankle ROM, and dynamic gait variables in subacute stage of lateral ankle sprain.