The relationship between norepinephrine (NE) and prostaglandins in the regulation of systemic blood pressure during pregnancy was examined in conscious rabbits. The arterial prostaglandin E2 (PGE2) concentration was higher in pregnant than in nonpregnant rabbits. Resting blood pressure was slightly lower in the gravid animals. The pressor response to incremental doses of intravenous NE was blunted in the pregnant rabbits. Meclofenamate, a cyclooxygenase inhibitor, failed to alter the resting blood pressure in either group of animals, although it reduced PGE2 levels more than 60% in the pregnant rabbits. The pressor response to NE was significantly increased only in the pregnant rabbits when the NE infusion was repeated following meclofenamate. Pregnant rabbits could also be differentiated from nonpregnant by their higher peripheral blood levels of NE and their uniform hypotensive response to alpha-adrenergic blockade. These observations define an altered responsiveness to both endogenous and exogenous NE in pregnant rabbits that appears to be related to an increase in vasodilator prostaglandins.

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Davitt, PM, Saenz, C, Hartman, T, Barone, P, and Estremera, S. Physiological impact of a single serving slow absorption carbohydrate on metabolic, hemodynamic, and performance markers in endurance athletes during a bout of exercise. J Strength Cond Res 35(5): 1262–1272, 2021—The purpose of this study was to determine how a slow-absorbing carbohydrate affected markers of metabolism, hemodynamics, and performance in well-trained endurance athletes. We examined total and exogenous carbohydrate oxidation (CHO ox), glucose, and performance after consuming different glucose beverages, before a treadmill run. Ten male runners (32.4 years; V̇o 2max, 55.9 ml·kg−1·min−1) participated on 3 occasions: slow digestion CHO (S), fast digestion CHO (F), and water (W). Subjects consumed a 50 g dose of either S or F before a 3-hour treadmill run at 57% V̇o 2max. Variables were assessed at −15, 0, 30, 60, 90, 135, and 180 minutes. Immediately postrun, subjects completed a time-to-fatigue test at 110% V̇o 2max. There was a significant difference in CHO ox for W vs. F and S (C,1.14; S,1.52; F,1.66 ± 0.2 g·min−1, p < 0.05). Fat ox was significantly higher in S vs. F (S,0.54; F,0.47 ± 0.08 g·min−1, p < 0.05). Exogenous CHO ox was significantly higher in F vs. S (F,0.26; S,0.19 + 0.04 g·min−1, p < 0.05). There was a significant difference in average blood glucose for trial (F,94.5; S,97.1 vs. W,88.4 + 2.1 mg·dl−1) and time × trial for F vs. S (0 minutes, p < 0.05). There were no significant performance differences. Consumption of a single bolus of CHO beverage before a 3-hour run elicits significant alterations in energy metabolism compared with just water, with S CHO oxidizing significantly more fat than a rapidly digested carbohydrate. These findings suggest that slow-digesting modified starch provides a consistent blood glucose level and sustained exogenous energy supply during a sustained, 3-hour endurance run. Significance was set at p < 0.05.

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