persons might have an additional risk of higher plasma levels of arylamine drugs co-administered with Buoxetine. Supporred by rhe Czech Ministy qf' Education Pmjecr: CEZ: JO7/98: 141100001 (dopamine D4 receptor) are counted among the most important, so called candidate genes. The NMR examination demonstrated changes in the size of basal ganglia, especially nucleus caudatus and striatum.

Symphysial osteomyelitis has been distinguished from osteitis pubis because of the more serious nature of the disease. We report a case in which there was a pelvic separation similar to that seen after trauma or pregnancy. The previously undescribed complications of bladder perforation and pelvic instability are also noted. There was no predisposing cause in this case, in contrast to the 40 previously reported. The causative organism was staphylococcus aureus, but pseudomonas aeruginosa and escherichia coli have also been found in other cases.

Long-term treatment of childhood asthma with theophylline or theophylline ethylenediamine (Aminophyllin) preparations requires dosage according to the various age groups. In order to achieve therapeutically satisfactory concentrations, estimations of theophylline levels in serum showed that in cases of good correlation between Aminophyllin dosage and theophylline levels smaller children required higher Aminophyllin doses than big children or adults. The therapeutic range of theophylline is around 7 to 15 mg/l beyond the newborn age. In order to obtain these concentrations children from the 1st to the 4th year require Aminophyllin doses of 6 mg/kg t.i.d., children between 5 and 12 years 5.5 mg/kg t.i.d. and adults beyond the 50th year of life 3 to 3.5 mg/kg t.i.d. Generally the first dose should be higher and is 6-7 mg/kg or 6-6.5 mg/kg or 4 mg/kg, respectively. Regular estimations of serum theophylline levels greatly help to improve safety of long-term treatment.

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