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In their editorial, Professor Lundbaek and his colleagues bring forth a number of noteworthy issues regarding capillary basement membrane thickening and the carbohydrate abnormalities of diabetes. Many of these points have been raised previously by Williamson [1] and no doubt some of them have concerned other investigators in this field. We are therefore pleased to attempt a clarification of these issues. Professor Lundbaek's editorial raises three critical questions:

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