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A sex difference in the biliary excretion of tartrazine, which occurs in the rat, has been found not to occur in the guinea-pig and rabbit. Male and female rats excrete 13 and 29% respectively of an intravenous dose of tartrazine (50 pmol/kg) in the bile in 3 h. The corresponding figures for male and female guinea-pigs and rabbits 13 (7.4-17) 61 (55-73) 74 (67-82) Female 29 (21-34) 55 (52-60) 84 (78-90) Guinea-pig . . . . Male 33 (31-37) 47 (41-51) 80 (72-87) Female 39 (30-49) 38 (24-51) 77 (74-8 1) Rabbit . . .. . . Male 4.5 (3.2-6.0) 61 (52-68) 66 (55-72) Female 5.8 (24-7.7) 67 (51-87) 73 (58-94)

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