The present study was designed to evaluate the cardioprotective effects of methanolic extract of Litsea deccanensis (MELD) against isoproterenol-induced myocardial infarction in rats by studying cardiac markers, lipid peroxidation, lipid profile, and histological changes. Male Wistar rats were treated orally with MELD (100 and 200 mg/kg) daily for a period of 21 days. After 21 days of pretreatment, isoproterenol (100 mg/kg) was injected subcutaneously to rats at an interval of 24 h for 2 days to induce myocardial infarction. Isoproterenol-induced rats showed significant (P < 0.05) increase in the levels of serum creatine kinase, lactate dehydrogenase, thiobarbituric acid reactive substances, and lipid hydro peroxides. The serum lipid levels were altered in the isoproterenol-induced myocardial infarcted rats. The histopathological findings of the myocardial tissue evidenced myocardial damage in isoproterenol-induced rats. The oral pretreatment with MELD restored the pathological alterations in the isoproterenol-induced myocardial infarcted rats. The MELD pretreatment significantly reduced the levels of biochemical markers, lipid peroxidation and regulated the lipid profile of the antioxidant system in the isoproterenol-induced rats. An inhibited myocardial necrosis was evidenced by the histopathological findings in MELD pretreated isoproterenol-induced rats. Our study shows that oral pretreatment with MELD prevents isoproterenol-induced oxidative stress in myocardial infarction. The presence of phenolic acid and flavonoid contents were confirmed by preliminary phytochemical tests. The reducing power and free radical scavenging activities of the MELD may be the possible reason for it pharmacological actions.

The study was conducted during spawning season (June-July) to evaluate the effect of Moringa oleifera seeds Petroleum Ether extracts (MPE) on gonad development and maturation of Mystus gulio. A total of 72 individual’s adult Mystus gulio (weighing from 72-110 g) were equally distributed in four different experimental groups in triplicate. Animals were fed with four different isonitrogenous and isocaloric diets viz. T1 (control), T2 (0.5 g MPE/kg), T3 (1 g MPE/kg) and T4 (1.5 g MPE/kg) for 35 days. Result of the experiment showed that the significantly (p<0.05) maximum oocytes growth, gonadosomatic index (GSI) value and hepatosomatic index (HIS) value in T3 experimental group followed by T2 group as compared to control. Histological observation of ovary deciphers the comparatively mature oocytes in T3 group. These mature oocytes are characterized by fusion of yolk granules, oil globules and thickening of egg chorion. Feeding with higher dose of MPE (T4) results in fatty liver and hepatocytes hypertrophy. This higher dose negatively affects the oocyte maturation, GSI and HSI of M. gulio. From the study it is concluded that the inclusion of 1 g of MPE/kg diet will improve the oocyte maturation, GSI and HSI in M. gulio cat fish.

This study was conducted in 4-year-old male child in sub-acute stage of Guillain Barre Syndrome (GBS) for 12 weeks in a local clinical setup after discharge from the hospital completing IVIG dose. Physiotherapy was given for 12 weeks, 5 days in a week of 1 and half hour session per day with rest periods between the session. Physiotherapy intervention includes passive – active exercise, resisted exercise, weight bearing exercise, mat activities, breathing exercises, task-oriented exercise, balance and coordination exercise, abdominal strengthening, gait training, and play activities. Outcomes used before and after the intervention were Manual Muscle Test (MMT), Five Times Sit to Stand Test (FTSST), Functional independent Measure (FIM), Time Up and Go test (TUG) and Hand dynamometer to analyse the effects of physiotherapy intervention. This study concluded that there was a significant improvement in patient’s motor functions and independence in daily activities after an effective physiotherapy treatment. There was a complete motor recovery after 12 weeks of physiotherapy.