Objective : Assessement of the oral health related quality of life of moroccan children with and without lip and palate clefts (CLP),before and after dental treatment using the Moroccan version of ECOHIS (early childhood oral health impact scale) : M-ECOHIS Patient And Method : Cross-sectional case-control study was conducted in a sample of 78children with CLP and their families within Operation smile Morocco and a control group of 97 children consulting in private dental practices, and the treatment outcomes in the same groups. Children's data were collectedusing the M-ECOHIS questionnaire. Results : we found a statisticly significant difference Degree of significance was set at p <0.05) between the quality of life of children with and without clefts in the overall M-ECOHIS scores and its subclasses. Before the treatment, the child Impact section showed a remarkable difference between these groups in the areas related to pain, difficulty in eating and drinking, difficulty in speaking and smiling. With regard to the difficulties faced by children with clefts, the question "Difficult to pronounce the words" obtained the highest mean score. The family section showed a statisticly significant(give the p founded) in financial difficulty. significant differences were found in the child impact section after dental treatment in all items except the difficulty in eating and drinking, for the difficulties experienced by the family, the financial impact scored the highest mean score (give the score). No significant differences were found between gender and sex, socioeconomic status, mother's educational level and oral status and the type of the cleft. Conclusion : This study allowed us to assess the effectiveness of the M-ECOHIS questionnaire, and to highlight the differences in the quality of life between patients with and without cleft lip and palate before and after the treatment

Salivary diagnosis is an increasingly important field in dentistry, physiology, internal medicine, endocrinology, pediatrics, immunology, clinical pathology, forensic medicine, psychology, and sports medicine. A growing number of drugs, hormones, and antibodies can be reliably monitored in saliva, which is an easily obtainable, non-invasive diagnostic medium It has become apparent that many systemic diseases affect salivary gland function and salivary composition. Studies of the effects of systemic diseases on salivary variables have been valuable in understanding the pathogenesis of the diseases, but their use as diagnostic markers has been limited. This article aims to review the point in the literature role of salivary biomarkers in systemic diseases.