Multiple sclerosis (MS) is a chronic disabling disease of the CNS that affects people during early adulthood. Despite several US FDA-approved medications, the treatment options in MS are limited. Many people with MS explore herbal products treatments to help control their MS and treat their symptoms. Surveys suggest that up to 70-80% of people with MS had tried plants products or bioactive compounds of plants for their MS. Patients with MS using herbal products potentially explore a new area for the research. The phyto therapies most frequently used include diet, omega-3 fatty acids and antioxidants. The most promising therapy for the anti-inflammatory and neuroprotective agents in both relapsing and progressive forms of MS were bioactive compounds of plant like flavonoids, vitamin-c, lipoic acid and vitamin D supplementation and others. In future polyphenols, terpenes, alkaloids, anthocyanidine glycosides, plant amines, volatile oils etc. would play a prominent role in the treatment of MS.