The aim of this research is to test the characteristics of concrete by substitute fine aggregate with iron ore tailings and partial glass powder as in the place of cement. Concrete with waste products such as glass powder and iron ore tailings offers technical, economic and environmental advantages. In this experimental investigation, glass powder is replaced with cement by 10%, 20% and 30% and iron ore tailings with fine aggregates by 30% which is the optimum percentage. To study the role of glass powder and iron ore tailings combination in concrete, The properties such compressive strength, flexural strength, tensile strength and also durability parameters likely water absorption investigation for M40 concrete is carried out with different percentages of glass powder by keeping the iron ore tailings percentage constant. At 30% glass powder substitution as cement and sand with IOT increases concrete effectiveness. The concrete with 10% glass powder & 30% iron ore tailings showed a higher strength compared to the conventional mix for 28 days. Concrete mix containing 10% GP and 30% IOT showed higher flexural strength of 5.05 MPa for 28 days. Splitting tensile strength value is also increasing i. e for 10% glass powder and 30% IOT, obtained splitting tensile strength was 4.48 MPa and modulus of elasticity value was has also increased. Water absorption experiment consequences results that water absorption decreases with an increase in GP percentage. The concrete workability tends to decrease when with glass powder content increase. Concrete containing 10% glass powder and 30% IOT showed maximum strength and it is considered as the optimum dosage.