The isomeric and tautomeric structure of I and II type monoacylated 5‐amino‐1,2,4‐triazole derivatives was studied with the help of their ir, uv, pmr and cmr spectra as well as model compounds prepared for this purpose. It was stated that the structure of the I type ring‐acylated derivatives is 2o and those of their II type isomers is 5a.

The amines (I) are converted to the chlorides (III), which undergo Gabriel synthesis to give the alkylene diamines (VI) and (VII).

The alkylation of 3‐R′‐thio‐5‐amino‐1H‐1,2,4‐triazoles 1 or their sodium salt with alkyl and aralkyl halides 2, respectively, to yield all the four possible monoalkylated derivatives 3, 4, 5 and 6 was studied. The comparison of the spectral data of different type isomers 3, 4, 5 and 6 isolated and their Schiff bases 8, 9 and 10, respectively, was unequivocal evidence in support of their structure which was then further supported by independent synthesis and ring closure reactions. According to an hplc study the main product of the alkylation is derivative 3, the by‐product is derivative 4, while derivatives 5 and 6 are formed only in insignificant amounts.

Die entsprechenden Pyrazole (Ia) oder (Ib) setzen sich mit DMF/POCI3 zu Aldehyden, wie z.B. (IV), um.

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