Background: Etiology of and outcomes following idiosyncratic drug-induced liver injury (DILI) vary geographically. We conducted a prospective study of DILI in India, from 2013 to 2018 and summarize the causes, clinical features, outcomes and predictors of mortality. Methods: We enrolled patients with DILI using international DILI expert working group criteria and Roussel Uclaf causality assessment method. Follow-up was up to 3 months from onset of DILI or until death. Multivariate logistics regression was carried out to determine predictors of non-survival. Results: Among 1288 patients with idiosyncratic DILI, 51.4% were male, 68% developed jaundice, 68% required hospitalization and 8.2% had co-existing HIV infection. Concomitant features of skin reaction, ascites, and encephalopathy (HE) were seen in 19.5%, 16.4%, and 10% respectively. 32.4% had severe disease. Mean MELD score at presentation was 18.8 ± 8.8. Overall mortality was 12.3%; 65% in those with HE, 17.6% in patients who fulfilled Hy's law, and 16.6% in those that developed jaundice. Combination anti-TB drugs (ATD) 46.4%, complementary and alternative medicines (CAM) 13.9%, anti-epileptic drugs (AED) 8.1%, non-ATD antimicrobials 6.5%, anti-metabolites 3.8%, anti-retroviral drugs (ART)3.5%, NSAID2.6%, hormones 2.5%, and statins 1.4% were the top 9 causes. Univariate analysis identified, ascites, HE, serum albumin, bilirubin, creatinine,

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To study the prevalence,histopathological types and pattern of distribution of colonic polyps in a cohort of patients evaluated in our tertiary care centre. Materials and Methods : Data of patients undergoing colonoscopy between 2017-2018 for various abdominal complaints were analysed retrospectively for presence of colonic polyps.Age , gender, clinical symptoms and histopathological analysis were also included in the study.Statistical analysis was done using SPSS 23.0 version to arrive at correlations between pattern of distribution and histopathological types. Results : A total of 1423 Colonoscopies were done during the 2 year period. Of them 152 cases were found to have Polyps including few patients with multiple polyps and overall a total of 207 Polyps were studied.Mean age of the study population was 57.61 years and most of them were males (77.6%).Polyps were more commonly located in rectum (20.3%) and sigmoid (25.1%).Most of the polyps were smaller in size <1cm (75.8%) and only few were >2cm (6.3%).Sessile polyps (77.3%) were more common then pedunculated (22.7%).Histology showed Adenomatous (63.7 %) followed by Hyperplastic (28%) and serrated (6.3%) were most common variety.Around 5.8% of polyps had high grade dysplasia and was more commonly seen in tubulovillous adenomas then tubular adenomas and also amongst serrated polyps. Conclusion : Colonic polyps were noted in around 10 % all colonoscopies and are less common in south Indian population then their western counterparts,however similar to west adenomatous polyp is the most predominant type of histology.Larger polyps and polyps with villous component and serrated polyps have more chances of having high grade dysplasia.

BISAP, HAPS, and SIRS scores and CRP of 150 mg/L all correlated significantly with the occurrence of fluid collections and pancreatic necrosis on CT at 72 h. None of the scores was superior to the other in this respect.

BackgroundInflammatory bowel disease (IBD) is increasingly diagnosed in South Asia. This survey by the Tamil Nadu Chapter of the Indian Society of Gastroenterology (TNISG) documents the demography, clinical profile, and therapeutic practices related to IBD in Tamil Nadu.MethodsTNISG members from 32 institutions completed an online cross‐sectional questionnaire on IBD patients from March 2020 to January 2021.ResultsOf 1295 adult IBD patients, 654 had Crohn's disease (CD), 499 ulcerative colitis (UC), and 42 IBD‐unclassified (IBD‐U). CD and UC showed a unimodal age distribution. A total of 55% were graduates or postgraduates. A positive family history was noted in 30, other risk factors were uncommon. In CD, the pattern of involvement was ileocolonic (42.8%), ileal (34.7%), colonic (18.9%), and upper gastrointestinal (3.5%); while in UC, disease was characterized as extensive (44.9%), left‐sided (41.7%), or proctitis (13.4%). Perineal disease, perianal fistulae, and bowel obstruction were noted in 4.3, 14.0, and 23.5%, respectively, of CD. The most widely used drugs were mesalamine, azathioprine, and corticosteroids. Surgery was undertaken in 141 patients with CD and 23 patients with UC. Of the 138 patients with pediatric IBD (≤16 years), 23 were characterized as very early onset IBD (VEO‐IBD), 27 as early‐onset, and 88 as adolescent IBD. VEO‐IBD were more likely to have a positive family history of IBD and were more likely to have perineal disease and to have the IBD‐U phenotype. Among pediatric IBD patients, corticosteroids, mesalamine, and azathioprine were the most commonly used medications, while 25 pediatric patients received biologics.ConclusionThis study provides important information on demography, clinical profile, and treatment practices of IBD in India.