The activity of cells from blood, peritoneal exudate, thoracic duct lymph, lymph nodes and spleen were tested in the adoptive secondary response of mice to hapten‐protein conjugates. No correlation of helper or antibody‐forming‐cell‐precursor activity was found with the number of macrophages. Thoracic duct lymphocytes tended to be relatively more active than spleen cells as helpers. These findings are interpreted as support for the hypothesis that helper cells are thymus‐derived, recirculating lymphocytes.

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The successful treatment of varicose veins is difficult, time consuming and tedious. A variety of surgical operations, including combinations of saphenofemoral ligation, stripping, multiple ligations, and ligation of perforating veins have been carried out with varying degrees of success. Injections of sclerosant solutions have been used to produce thrombotic occlusion which is usually ineffective and sometimes dangerous. Recently a new method of treatment by injection and compression (Fegan, 1953-4) has aroused considerable interest and controversy. Sclerosant solution is injected into an emptied segment of vein in order to damage the intima and initiate inflammation. Compression is then applied to appose the walls of the vein and reduce the size of any thrombus to a minimum. The lumen becomes occluded by fibrosis and the vein converted to a fibrous cord. This paper reports the results of this method of treatment in a series of 264 patients who were treated at the West All patients were treated in a special clinic to which they were referred from the surgical outpatient clinics and injections were performed by a number of surgical registrars and consultants. Patients with primary saphenofemoral incompetence or major varices in the thigh, which could not be compressed adequately with a bandage, were not accepted for sclerosant therapy. Women were advised to stop taking oral contraceptives for two cycles before treatment was started and until treatment was complete. Patients with varicose ulcers were treated, before injections were given, by dressings and bandaging until the ulcer was clean enough to withstand six weeks of bandaging.Sites of perforating veins were identified by palpation with the patient flat and the limb raised. The course of the varices and the sites of the perforators were then marked with the patient standing, and the markings recorded in the notes on a rubber stamp outline. Injections were begun distally with the patient lying down. A 17 gauge needle was introduced into the vein and blood drawn From: The West Middlesex Hospital, Isleworth.

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