ObjectivesTo evaluate the diagnostic yield (DY) of ultrasound guided FNA of gastrointestinal walls (GI) and to assess predictors of success.

> A 10-year-old female neutered miniature schnauzer presented with multifocal ulcerative and crusting lesions affecting the vulva, nasal planum, lips and oral mucosa (Figure 1). Biopsy samples were supportive of PV or paraneoplastic pemphigus. Upon referral, extensive imaging ruled out the latter. > Lesions were improved by immunosuppressive therapy with PO prednisolone (2mg/kg SID) and ciclosporin (5mg/kg BID). Chlorambucil (2mg SID) and oclacitinib (0.3mg/kg SID) were sequentially added which allowed to achieve remission.> Chlorambucil was stopped after development of neutropenia and oclacitinib as part of drug tapering. cm> PV is one of the rarest autoimmune dermatosis with only 54 canine cases reported in the literature 1 .There is no consensus guidelines for the treatment of PV in companion animals and reported regimens vary widely 2 .> Oclacitinib is a selective Janus kinase (JAK) inhibitor. JAK are involved in the signaling and transduction of many proinflammatory cytokines including IL-2, IL-4, IL-6, IL-13, and IL-31 3 . Human literature seems to indicate a role of JAK in the pathogenesis of PV with, among the key mediators, IL-4 and IL-6 4 .> The successful usage of oclacitinib, off-label, is increasingly described in autoimmune skin disease. Reports include a case of feline pemphigus foliaceus 5 , a dog with subepidermal blistering dermatosis 6 , 2 dogs with hyperkeratotic erythema multiforme and 4 dogs presenting a juvenile ischaemic dermatopathy 7 .

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