Background and Purpose Increased angiogenesis in head and neck squamous cell carcinoma correlates to more aggressive tumors with increased morbidity. As both elevated blood flow and high serum CXCL8 levels are correlated with increased angiogenesis, our objective was to see if elevated blood flow measured with CT perfusion correlated with CXCL8 levels, thereby helping to identify candidates for targeted therapies that inhibit the Bcl-2 proangiogenic pathway associated with CXCL8. Materials and Methods After IRB approval, 7 patients with locally recurrent or metastatic HNSCC were enrolled in the trial. They underwent CT perfusion and the following parameters were measured: BV, BF, CP, and MTT; relative values were calculated by dividing by normal appearing muscle. These patients also had serum drawn for CXCL8 ELISA analysis. Results There was a significant positive correlation between the CXCL8 levels and rBF (rho=0.94; p=0.01). No correlation was found between CXCL8 and rBV, rCP, or rMTT. Conclusion rBF may be useful as a surrogate marker for elevated CXCL8 in patients with head and neck squamous cell cancer. Patients with elevated rBF may benefit from treatment targeting the Bcl-2 proangiogenic pathways.