A 13-year-old Greek girl with pyruvate kinase deficiency and moya moya angiographic pattern is reported. She also had raised serum lipoprotein (a) concentration and was homozygous for the C677T mutation of the methylenetetrahydrofolate reductase gene. She presented with neonatal onset of anemia, hemolytic and aplastic crises, especially during infections, stroke, and also progressive motor and mental deterioration. A digital cranial angiography at 13 years revealed the typical angiographic findings of moya moya angiopathy. This is likely the first patient with pyruvate kinase deficiency and moya moya syndrome and also the combination of elevated serum lipoprotein (a) concentration and the C677T mutation of the methylenetetrahydrofolate reductase gene to be reported. In patients with pyruvate kinase deficiency and moya moya syndrome, a search for raised serum lipoprotein (a) concentrations and the C677T mutation of the methylenetetrahydrofolate reductase gene should be considered.

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ABSTRACT. Objective of the study was to confirm efficacy of intervention by means of a rabbit. We studied and recorded reactions of pupils and personnel in the presence of a rabbit in a comprehensive-type kindergarten. We selected a group of 39 clinically healthy pupils, 2.5-to 4-year-old, who were attending the kindergarten and used relevant weighted questionnaires for pupils and teachers. In the presence of the animal, pupils' ability of socializing, communicating and expressing emotions increased significantly. Teachers also found the results of the intervention particularly positive. It is concluded that rabbit intervention in a public kindergarten is feasible, low cost and does not require specialized personnel. The rabbit is a popular animal, familiar to children, hence the intervention was successful and effective as similar interventions with dogs, providing the chance to children to learn and become accustomed to animals.Keywords: animal assisted intervention, dog, kindegarten, pet, rabbit ΠΕΡΙΛΗΨΗ. Μελετήθηκαν και καταγράφηκαν οι αντιδράσεις μαθητών και μελών του προσωπικού σε δημόσιο νηπιαγωγείο. Επιλέχθηκε μια ομάδα από 39 κλινικά υγιή νήπια, ηλικίας 2,5 έως 4 ετών. Έγινε χρήση σχετικού σταθμισμένου ερωτηματολογίου για τα νήπια και τους εκπαιδευτικούς του νηπιαγωγείου. Με την παρουσία του ζώου, αυξήθηκε σημαντικά η ικανότητα κοινωνικοποίησης, επικοινωνίας και έκφρασης συναισθημάτων των νηπίων. Οι εκπαιδευτικοί θεώρησαν την

This study was undertaken in order to evaluate the cytogenetic and immunological responses to the effective, harmless and world-wide used vaccines of I. rubella and II. measles-mumps-rubella (M-M-RII). In one group (A) of five girls vaccinated against rubella and in another group (B) of four boys and two girls vaccinated against measles-mumps-rubella, the following parameters were studied before and repeatedly after vaccination: (a) SCE frequency, in peripheral lymphocytes, (b) DNA-synthesis, in peripheral mononuclear cells, and (c) antibody titres. The mononuclear cell proliferation rate was elevated between the 3rd and 7th day, preceeding the humoral immunological reactions, which began after the 25th day (group A) and the 28th day (group B). The latter findings coincided with a significant increase of SCE frequency in group A (one child) and in group B (all six children); in no case did the highest SCE/cell ratio exceed the normal value.