1. The milk yield of eight mothers each breast-feeding twins was determined by test weighing the mothers. Milk yield was determined at 2, 3, 6, 9, and 12 months post partum; however, only one mother was studied at all these times.2. At 6 months post partum the milk yield for individual breasts of three mothers fully breast-feeding and four mothers partially breast-feeding their infants ranged from 0.84 to 2.16 kg/24 h and 0.42 to 1.39 kg/24 h respectively. The average frequency of breast-feeding for the mothers studied at 6 months post partum was 15.4 feeds124 h.3. The milk yield of one mother fully breast-feeding 2.5-month-old triplets was 3.08 kg/24 h and the infants were fed twenty-seven times in 24 h.4. The concentration of lactose, protein and mixed fat in the milk from individual breasts of mothers fully breast-feeding their infants ranged from 65.6 to 82.2, 7.8 to 15.7 and 16.7 to 46.2 g/1 respectively. For the three mothers partially breast-feeding 12-month-old infants the values ranged from 54.8 to 71.8, 14.2 to 19.9 and 4.7 to 40.5 g/l respectively.5. At 6 and 12 months of age, the proportion of the total energy intake of the infants which was derived from breast milk ranged from 64 to 100% and 6 to 13% respectively.6. It is concluded that the maximum potential milk yield for women may be higher than the often quoted value of 70–800 m1/24 h.

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Coronary computed tomography angiography (CCTA) has emerged as the preferred modality in the diagnosis of coronary artery disease, but it is limited by modest specificity. By applying principles of computational fluid dynamics, flow fraction reserve, a measure of lesion-specific ischemia that is used to guide revascularization, can be noninvasively derived from CCTA, the so-called computed tomography–derived flow fractional reserve (FFRCT). The accuracy of FFRCT in discriminating ischemia has been extensively validated, and it has been shown to improve the specificity of CCTA. Compared to other stress myocardial perfusion imaging, FFRCT has superior or comparable accuracy. Clinical studies have provided strong evidence that FFRCT has significant prognostic implications and informs clinical decisions for revascularization, serving as a gatekeeper to invasive coronary angiography. In addition, FFRCT-based tools can be used to simulate the physiological consequences of different revascularization strategies, thus providing the roadmap to achieve complete revascularization. Although challenges remain, ongoing research and randomized controlled trials are expected to address current limitations and better define its role in clinical practice.

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