Multiple input multiple output system have been emerged technology to increase channel capacity and a technical breakthrough for high data rate wireless transmission. The main objective of MIMO system is to obtain low Symbol Error Rate (SER) and acceptable computational complexity. The MIMO system cannot be implemented due to complexity problem. The complexity of MIMO system can be reduced by using different detector algorithms. In this paper, the performance of MIMO system over AWGN (Additive White Gaussian Noise) with ZF, MMSE, SD, K best algorithm and SSFE are analyzed using different antenna configuration. The Bit Error Rate performance of all detectors are studied for 16QAM modulation technique using AWGN channel for the analysis purpose and their effect on BER (Bit Error Rate) have been presented.