The synthesis and characterization of Co(II) and Ni(II) mixed ligand complexes are derived from isoniazid, 9-fluorenoneandoxalate. The metal complexes were characterized on the basis of elemental analysis, IR, UV-visible, CV, PXRD, and molar conductance analytical data, viz., all the metal complexes were suggested in an octahedral geometry, respectively. The mixed ligand complexes are formed in the 1:1:2:1 (M:L1:L2:L3) ratios, as found from the elemental analyses, and originate to have the formula [M(L1)(L2)2(L3)]. Where M = Co(II), Ni(II), L1 = isoniazid,L2= 9-fluorenone, and L3 = oxalate. The molar conductance data reveals that the complexes are non-electrolytes. The cyclic voltammogram of the Co(II) complex revealed that the quasi-reversible single electron transfer process and Ni(II) complex corresponding to a one-electron transfer process were observed during controlled potential electrolysis. IR spectra show that the ligands are coordinated to the metal ions through N and O donor sites of isoniazid-N, 9-fluorenone-O and oxalate-O. Magnetic moment values and UV-visible spectra were used to infer the coordinating of the geometrics of these complexes found to be octahedral. The PXRD patterns suggest that all the complexes are crystalline phases. The metal chelates have been screened for antimicrobial, antioxidant and anti-inflammatory activities, and our findings have been reported, explained and compared with some known antibiotics.
2,4-Dinitrophynylhydrazine and two thiocyanate ions in a (M:L1:L2) 1:2:2 molar ratio was synthesized in the complexes of Co(II) and Ni(II). The prepared compounds were identified through a C.H.N.S. analysis, conductivity measurements, powder X-ray diffraction (PXRD), the infrared spectrum, and a UV-visible spectrum analysis, in addition to the magnetic properties being measured. The measurements of the molar conductance implieda nonelectrolytic nature of compounds Co(II) and Ni(II). The magnetic susceptibility, as well as electronic spectra, represented all the metal complexesthroughoctahedral geometry, respectively. The PXRD patterns suggested that all the complexes were an orthorhombic system with unit cell parameters. The in-vitro biological activity of the ligand and the metal complexes were screened against the Gram-positive and negative pathogenic bacteria Staphylococcus aureus, Bacillus subtilis, Pseudomonas, aeruginosa and Escherichia coli, as well as the fungal species of Aspergillusniger and Candida albicans.Thus, the metal complexes showeda high efficiency of antimicrobial activity compared with the ligand. Furthermore, applications of the ligand, as well as the metal complexes, were tested for in-vitro antioxidant potential in aDPPH assay. The results showed that the activity of the metal complexes with the in-vitro antioxidant was more active than that of 2,4-dinitrophenylhydrazine(DNPH).
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