Background: Short and long-term sequelae after admission to the intensive care unit (ICU) for coronavirus disease 2019 are to be expected, which makes multidisciplinary care key in the support of physical and cognitive recovery. Objective: To describe, from a multidisciplinary perspective, the sequelae one month after hospital discharge among patients who required ICU admission for severe COVID-19 pneumonia. Design: Prospective cohort study. Environment: Multidisciplinary outpatient clinic. Population: Patients with severe COVID-19 pneumonia, post-ICU admission. Methods: A total of 104 patients completed the study in the multidisciplinary outpatient clinic. The tests performed included spirometry, measurement of respiratory muscle pressure, loss of body cell mass (BCM) and BCM index (BCMI), general joint and muscular mobility, the short physical performance battery (SPPB or Guralnik test), grip strength with hand dynamometer, the six-minute walk test (6-MWT), the functional assessment of chronic illness therapy-fatigue scale (FACIT-F), the European quality of life-5 dimensions (EQ-5D), the Barthel index and the Montreal cognitive assessment test (MoCA). While rehabilitation was not necessary for 23 patients, 38 patients attended group rehabilitation sessions and other 43 patients received home rehabilitation. Endpoints: The main sequelae detected in patients were fatigue (75.96%), dyspnoea (64.42%) and oxygen therapy on discharge (37.5%). The MoCA showed a mean score compatible with mild cognitive decline. The main impairment of joint mobility was limited shoulder (11.54%) and shoulder girdle (2.88%) mobility; whereas for muscle mobility, lower limb limitations (16.35%) were the main dysfunction. Distal neuropathy was present in 23.08% of patients, most frequently located in lower limbs (15.38%). Finally, 50% of patients reported moderate limitation in the EQ-5D, with a mean score of 60.62 points (SD 20.15) in perceived quality of life. Ivyspring International PublisherConclusions: Our findings support the need for a multidisciplinary and comprehensive evaluation of patients after ICU admission for COVID-19 because of the wide range of sequelae, which also mean that these patients need a long-term follow-up. Impact on clinical rehabilitation:This study provides data supporting the key role of rehabilitation during the follow-up of severe patients, thus facilitating their reintegration in society and a suitable adaptation to daily living.

reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. carbon dioxide 30 [27][28][29][30][31][32][33][34][35] mmHg and median temperature 37.1 [36.8-37.3]°C. After removal of artefacts, the mean monitoring time was 22 h08 (8 h54). All patients had impaired cerebral autoregulation during their monitoring time. The mean IAR index was 17 (9.5) %. During H 0 H 6 and H 18 H 24 , the majority of our patients; respectively 53 and 71 % had an IAR index > 10 %. Conclusion According to our data, patients with septic shock had impaired cerebral autoregulation within the first 24 hours of their admission in the ICU. In our patients, we described a variability of distribution of impaired autoregulation according to time. ReferencesSchramm P, Klein KU, Falkenberg L, et al. Impaired cerebrovascular autoregulation in patients with severe sepsis and sepsis-associated delirium. Crit Care 2012; 16: R181. Aries MJH, Czosnyka M, Budohoski KP, et al. Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury. Crit. Care Med. 2012.

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Learning Objectives: National estimates of CPR and associated outcomes in hospitalized stem cell transplant(SCT) recipients are unclear. We conducted this study to evaluate the impact of CPR on hospital charges (HC), length of stay (LOS), and in-hospital mortality(IHM) in adults undergoing SCT and to examine patient-level factors associated with having CPR. We hypothesized that use of CPR is associated with poor outcomes and that a mix of patient level factors is associated with risk of having a CPR. Methods: The Nationwide Inpatient Sample for the years 2004 to 2010 was used to select all patients >18 years who had SCT procedures. Performance of CPR in this cohort was identified and its impact on HC and LOS examined by multivariable linear regression analyses. For IHM, multivariable logistic regression was used. The effects of confounding factors such as age, sex, race, insurance status, type of SCT, type of admission, co-morbid burden, hospital teaching status, and hospital region were adjusted. A heterogeneous mix of patient related factors on the odds of having CPR was computed by using multivariable logistic regression analysis. Results: 85,772 patients had SCT. The mean age was 50.7 yrs and 59% were males. CPR was performed in 0.3% of patients. Outcomes(wCPR vs woCPR)include: median charges ($264,104 vs $191,471), median LOS days(21.1 vs 20.3), respectively. CPR was associated with significantly higher HC(23.5% higher, p=0.01). LOS was not significantly associated with CPR following adjustment of confounders. IHM(wCPR vs woCPR) was 78.2% vs 4.3%.(wCPR: OR=112, 95% CI=35-361, p<0.0001, ref woCPR). Blacks (OR=2.39, 95% CI=1.06-5.40, p=0.04, reference whites), increase in comorbid burden(OR=1.42, 95% CI=1.24-1.62, p<0.0001), and those who developed septicemia (OR=2.95, 95% CI=1.51-5.78, p<0.0001) or pneumonia (OR=3.27, 95% CI=1.69-6.33, p<0.0001) were associated with significantly higher odds for having CPR. Conclusions: In this large cohort of SCT recipients nearly 1 in 330 had CPR. The associated mortality and hospital resource utilization is significant. Certain predictors of risk of having CPR are identified. 272