Results: Parity was associated with 78% decreased risk of cause-specific mortality in 243 women with germ cell tumors (GCTs); adjusted for age at diagnosis. Especially malignant teratomas seem to be less deadly among parous women. Among women diagnosed with malignant teratomas at age 30 years and older (n¼77), 6% of the parous women died of their disease, compared with 23% of the nulliparous women (p¼0.03). We found no evidence of associations between parity and cause-specific mortality among the 334 patients with sex cord-stromal tumors, nor among the 3214 patients with epithelial ovarian cancer; neither overall, nor by subtype. Table: 762P Associations between parity and cause-specific mortality among patients with ovarian germ cell tumors in Sweden 1990-2018. Hazard ratio (HR) and 95% confidence intervals (CIs) from Cox regression models, adjusted for age at diagnosis Parity (ever) n Mean age at diagnosis HR 95% CI (p-value) No 135 27 years 1.00 Ref Yes 108 38 years 0.22 0.07-0.62 (p¼0.005) Per birth 0.60 0.38-0.95 (p¼0.03) .Conclusions: In this large, population-based study, parity was associated with better prognosis in GCTs but not in the other ovarian cancer subtypes, potentially indicating that parous women develop less aggressive GCTs. Future research on how hormone exposure impact on GCT development may lead to better understanding of potential mechanisms affecting survival.Legal entity responsible for the study: The authors.

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