Orofacial Granulomatosis (OFG) is a rare clinicopathological entity characterized clinically by the presence of continuous enlargement of the soft tissues of the oral and maxillofacial region and histologically by non-caseating and non-necrotizing granulomatous inammation. The term 'orofacial granulomatosis' has been introduced to indicate the group of various disorders, involving Melkersson-Rosenthal syndrome and granulomatous cheilitis and has been noted to be associated with Sarcoidosis, Crohn's disease and infectious diseases such as Tuberculosis. But, various etiological agents such as food additives, dental materials and microbial agents have been recommended in the disease process. Treatment of orofacial granulomatosis is by corticosteroids but it's not so efcient. It is more important to nd the pathogen rst to specify the appropriate treatment line.