Relapsing polychondritis (RP) is an uncommon autoimmune disease with varying clinical presentations. Relapsing polychondritis frequently involves the ear, nose, and throat cartilages, often causing subtle and episodic symptoms that can pose a diagnostic challenge to the otolaryngologist. A high index of suspicion is needed to identify these subtle signs leading to early diagnosis. Here, we report a case of RP presenting with hoarseness of voice; we reviewed the literature and clinical signs discussed from an otolaryngologist's perspective. Greater awareness about its episodic and myriad presentation is needed for early diagnosis and management of this uncommon clinical condition.