Background: The 2019 Coronavirus disease (COVID-19) has caused a global distress. However, its psychological impact on patients is unclear. We aim to determine the mental health status and explore related factors of anxiety and depression among patients with . Methods and main outcome measures: This is a cross-sectional descriptive survey conducted among COVID-19 patients at the Mohammed VI University Hospital Centre in Marrakech over a period of four months. We assessed symptoms of depression and anxiety using the Arabic version of the Hospital Anxiety and Depression Scale (HADS) on admission. The significance threshold used for any data comparison test was the value of p < 0.05. Results: A total of 103 participants were included. The average age was 44, 17 ± 17, 19 years. About 54,4% of the subjects were male. Of the 103 participants, 36.89% and 23.30% patients with COVID-19 had symptoms of anxiety or depression; respectively. The mean score of anxiety subscale and depression subscale for all patients was 6.45 ± 4.29 and 5.38 ± 4.47, respectively. The bivariate analysis showed that age (p=0, 0004; p=0, 0002), oxygen saturation level (p=0, 0003; p=0, 0059), hospital stay (p <0, 0001; p <0, 0001) and family infection with SARS-CoV-2 (p=0, 0094; p=0, 0023) were associated with anxiety and depression respectively for COVID-19 patients. Moreover, gender (p=0, 0119) was associated with depression. Conclusion:There is an increasing level of anxiety and depression in hospitalized patients with COVID-19. Mental concern and appropriate intervention remain an important part of clinical care for those who are at risk.

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