Diffusive sampler monitoring techniques were employed during wintertime studies from 2009 to 2012 to assess the spatial distribution of air pollutants associated with the Pinedale Anticline and Jonah Field oil and natural gas (O&NG) developments in the Upper Green River Basin, Wyoming. Diffusive sampling identified both the extent of wintertime ozone (O 3) episodes and the distributions of oxides of nitrogen (NO x), and a suite of 13 C 5 + volatile organic compounds (VOC), including BTEX (benzene, toluene, ethylbenzene and xylene isomers), allowing the influence of different O&NG emission sources to be determined. Concentration isopleth mapping of both diffusive sampler and continuous O 3 measurements show the importance of localized production and advective transport. As for O 3 , BTEX and NO x mixing ratios within O&NG development areas were elevated compared to background levels, with localized hotspots also evident. One BTEX hotspot was related to an area with intensive production activities, while a second was located in an area influenced by emissions from a water treatment and recycling facility. Contrastingly, NO x hotspots were at major road intersections with relatively high traffic flows, indicating influence from vehicular emissions. Comparisons of observed selected VOC species ratios at a roadside site in the town of Pinedale with those measured in O&NG development areas show that traffic emissions contribute minimally to VOCs in these latter areas. The spatial distributions of pollutant concentrations identified by diffusive sampling techniques have potential utility for validation of emission inventories that are combined with air quality modeling.