These data show that exclusion of glibenclamide in the treatment of ICA+ type 2 diabetic patients partially decreases specific autoimmunity against endocrine pancreatic cells and improves metabolic control. This may reflect decreased expression of B-cell autoantigens suggesting that insulin monotherapy is a better choice for the treatment of LADA.

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Celiac disease does not seem to be related with pancreatic autoimmunity in type 2 diabetes. Celiac disease causes a decrease of body mass index in type 2 diabetes while pancreatic islet autoimmunity in this entity masks this effect.

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With 1 Figure Summary. Active rosette forming T lymphocytes (ARTL) represent a subpopulation of T cells with high affinity for sheep erythrocytes. It has been postulated that ARTL reflect the cellular immune status in the human, and in earlier papers we have hypothesized their suppressor activity. In this work ARTL were determined by the method of Wybran. We studied 58 insulin dependent diabetics (IDD), 30 non-insulin dependent diabetics (NIDD) with HbA1c below 8%, and 41 NIDD with HbA0c higher than 8% at the moment of taking the sample. Healthy blood donors were used as controls. We observed a significaut decrease of ARTL in IDD at the onset of the disease Normal values were restored from the third month after manifestatibn ARTL were normal in both groups of NIDD. These findings suggest that insulin may exert an influence on ARTL.