The present study aimed to observe impact of listening to OM chanting and Mahishasura Mardini Strotram (Stotra on Devi Durga) on perceived stress, and cognition in underweight females. 15 under weight females and 15 age matched controls were included in the study after obtaining voluntary, informed consent by convenience sampling. Stress levels were assessed by perceived stress scale. Cognitive functions were assessed by MMSE, spatial and verbal memory test and auditory and visual reaction time. Our study provides preliminary evidence for beneficial effects of listening to OM chanting and Mahishasura Mardini Strotram on stress and cognitive functions. We recommend further detailed studies, with higher sample size and including both genders and more parameters for proving further strong evidences to support incorporation of listening to OM chanting and Mahishasura Mardini Strotram in daily life for better quality and quantity of life.