Reducing the cost of the synthesis process and device fabrication plays an essential role in modestly developing products. In the present report, a simple and low-cost approach for the synthesis of ZnO nanosheets and the fabrication of a piezoelectric nanogenerator is developed. The ZnO nanosheets are synthesized by hot plate assisted hydrothermal method and characterized for their morphology, crystallinity, composition. The fabricated nanogenerator device produced an open-circuit voltage of ∼220 mV upon finger tapping. The series connection of seven such devices produced an open-circuit voltage of ∼1.2 V. The ZnO nanosheets films synthesized at a growth temperature of 85 °C for a growth duration of 4 h are found to be optimum parameters for making the nanogenerator device with high output. The nanogenerator response is recorded for different frequencies of finger tapping and different finger-tapping pressures. Further, the fabricated nanogenerator exhibited a stable output response over 1100 cycles confirms the high durability of the fabricated device. The fabricated nanogenerator is explored further for pressure sensing application.

A sensitive, rapid, precise, accurate high-performance liquid chromatographic method was developed for the estimation of Sorafenib (SOR) in the tablet dosage form. Chromatographic separation of SOR was carried out utilizing thermo-scientific model C18 column (4.6 mm i.d. X 250 mm; 5µm particle size) (based on 99.99 % ultra-high purity silica) using mobile phase that consisting of acetonitrile: methanol (40:60 v/v) at a flow rate of 1.0 mL/min. The absorption maximum (?max) of SOR in the mobile phase was found to be 265.5 nm. It had a retention time of 3.223 min. The calibration curve was in linear function of the drug in the concentration range of 2-10 µg/mL (r2 = 0.999) for the optimized method. The regression equation for SOR was found to be Y = 68228 x + 8071. The Detection Limit (DL) & Quantitation Limit (QL) results of SOR were found to be 0.526 µg/mL and 1.594 µg/mL respectively. The developed method was validated in pursuance of ICH Q2 (R1) guidelines. The method was linear, precise, accurate with recoveries in the range of 98 - 102 %, and minimum values of % RSD indicate the accuracy of the method. The detailed quantitative results of the study show that this method is precise, accurate, and cost-effective. Thus, the developed RP-HPLC method can be successfully feasible for the routine quality control analysis of SOR in a pharmaceutical dosage form.

The increasing food packaging waste is a severe concern for air, water, and soil pollution. In this research work, a triboelectric nanogenerator (TENG) is fabricated using waste food packaging Aluminium cover foils and laboratory parafilm for the first time. The device novelty lies in the selection of the materials; parafilm and food packing Aluminium cover foils. The proposed TENG produced an output voltage and instantaneous power density of ∼4 V and 11.8 nW cm −2 , respectively, by hand excitation force. Further, TENG can easily power up 85 commercial light-emitting diodes, digital watch, thermometer, and calculator with the help of charged capacitor. The proposed TENG demonstrated the ease of process, simplicity, cost-effectiveness, and reduction of pollution. Further, this TENG performance can be improved with other triboelectric materials and applied in selfpowered portable electronic device applications.

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We report a double-fold enhancement of piezoelectric nanogenerator output voltage with a simple design strategy. The piezoelectric nanogenerator is fabricated with ZnO nanosheets coated on both sides of the aluminum substrate in this new design strategy with necessary electrodes. The cost-effective hydrothermal method is employed to synthesize two-dimensional (2D) ZnO nanosheets on both sides of the aluminum substrate at a low growth temperature of 80 °C for 4 h. The ZnO nanosheets were characterized for their morphology, crystallinity, and photoluminescence property. The performance of nanogenerator fabricated with double-side coated aluminum substrate was compared to single-side coated aluminum substrate. The nanogenerators fabricated only with one side coating produced an output voltage of ∼170 mV. In contrast, the nanogenerators fabricated with double side coating produced an output voltage of ∼285 mV. The nanogenerator with double-side coating produced ∼1.7 times larger output voltage than that of single-side coated one. The enhancement in the output voltage is mainly due to ZnO nanosheet deformation along both sides and the electric field-induced synergetic effect between two front and back sides of piezoelectric nanogenerators. This nanogenerator fabrication technology has the potential to be scaled up for industrial production of piezoelectric energy collecting devices because of its simplicity and high output gain.