Acute pancreatitis in its severe form may lead to systemic inflammatory response syndrome and multisystem organ dysfunction. Acute lung injury is an important cause of mortality in the setting of severe acute pancreatitis. Besides lung involvement, acute and chronic pancreatitis may also lead to the involvement of other thoracic compartments, including mediastinum, pleura, and vascular structures. These manifestations are an important cause of morbidity and may pose diagnostic and therapeutic challenges. These manifestations have not been discussed in detail in the available literature. In this review, we discuss the thoracic complications of pancreatitis, including lung, pleural, mediastinal, and vascular manifestations.
CN OH O Ar NH 2 R' R Ar-CHO R + + TiCl 4 r.t 1 2 3 4a-tThree component coupling of one pot reaction which servers as the most convenient route to the synthesis of benzopyran derivatives using the TiCl 4 catalyst (10 mol %) under solvent free conditions is described. The procedure offers a systematic method with a number of advantages including operational simplicity, neat reactions, reduced reaction time, high yields of products and applicability to large scale reactions.
An efficient, one-pot multicomponent synthesis of novel naphthalimide-based acridine-1,8-dione derivatives was achieved by condensation of dimedone, aromatic aldehydes, hydrazine hydrate, and 1,8-naphthanoic anhydride in the presence of a [bmim]HSO 4 ionic liquid, which acts as a green solvent medium. Mild conditions with excellent conversions and a simple isolation procedure are noteworthy advantages of this method. The recovery and recyclability of the ionic liquid make this protocol environmentally desirable.
A 26-year-old male presented with complaints of dry cough of six months and progressive breathlessness of three months duration. He was coughing out milky white sputum for two months and had lost 12 kg weight in two months. He had an evening rise in temperature of one month duration. Clinically, the patient was in respiratory distress and the respiratory system examination revealed bilateral velcro crackles. High resolution computed tomography chest showed bilateral diffuse reticulonodular opacities and “Crazy Paving” pattern suggestive of alveolar proteinosis. Broncho alveolar lavage showed eosinophilic granular material, which was periodic acid-Schiff positive. Open lung biopsy was done to confirm the diagnosis and the histopathologic examination revealed eosinophilic secretions with granular appearance suggestive of pulmonary alveolar proteinosis. Subsequently, patient underwent bilateral sequential whole lung lavage under general anesthesia. Patient showed marked clinical and radiological improvement after sequential whole lung lavage.
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