is an International, peer-reviewed scientific journal that publishes original article in experimental & clinical medicine and related disciplines such as molecular biology, biochemistry, genetics, biophysics, bio-and medical technology. JMS is issued four times per year on paper and in electronic format.

Amlodipine is a fourth generation dihydropyridine derivative calcium channel blocker, mainly used in the treatment of hypertension, angina and certain other cardiac disorders. It is an L-type Ca2+ channel blocker, which leads to inhibitory action on the sympathetic N-type Ca2+ channels. The oral bioavailability of amlodipine is between 64% and 90%. The longer duration of action of amlodipine is due to a combination of high bioavailability, slow clearance and long half-life where by plasma concentration of the drug is above minimum effective concentration for a long time and show sustained efficacy. The most frequently occurring adverse effect with amlodipine therapy includes palpitation, flushing, ankle edema, hypotension, headache and nausea. PedaPl edema is a common adverse effect of calcium channel blocker (Amlodipine, Nifedipine, Diltiazem, Felodpine, Isradipine). We report a patient who developed pitting type pedal edema after treating with amlodipine for hypertension.Keywords: Amlodipine; Glimepride; Pedal edema Case DescriptionA 43 yrs old male patient was admitted to general medicine ward with complaints of swelling of the legs. On further interviewing, he was a known case of diabetes mellitus, under oral hypoglycemic agent of glimepride 2 mg and metformin 500 mg for past 1 yr. Before 3 months the patient was also diagnosed with hypertension and was under irregular medication.By examining the vital sign, blood pressure was found to be 160/90 mmHg, pulse rate 78 beats per minute and all other laboratory investigations such as complete blood count, liver function test urine analysis, chest X ray, electrocardiograph seems to be normal. The diabetic profile shows Random blood glucose -262 mg/dl, HbA1C-7%. From the subjective, laboratory examination and past history of the patient he was diagnosed with type II diabetes mellitus and hypertension. The patient was treated with glimepride 2 mg, metformin 500 mg and amlodipine 2.5 mg orally once daily. On the 4th day after initiation of amlodipine therapy, the patient was presented with pedal edema (pitting type). The physician interprets that the pedal edema was caused by amlodipine. On cessation of amlodipine the patient was recovered from edema and an alternative anti-hypertensive agent, telmisartan 40 mg and hydrochlorothiazide 12.5 mg once daily was prescribed.

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A 22-year-old Indian female patient was admitted in female General Medicine ward with the chief complaints of increased abdominal pain, fever, fatigue and yellowish discoloration of skin and eyes ( Figure 1). She was a known case of SLE and seizure and she was under treatment with azathioprine and phenytoin for past 5 months. During physical examination patient was conscious and co-operative. Lab investigations revealed elevated liver enzymes (Table 1).

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