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A stereoselective total synthesis of phomolides G and H, a polyketide natural products is described. The synthesis involves organocatalytic enantioselective asymmetric epoxidation, C1-Wittig olefination, and ring-closing metathesis as key steps. The use of organocatalytic MacMillan asymmetric epoxidation for the construction of two chiral centers of phomolides G and H makes this approach more attractive.

A Prins cascade process was developed for the synthesis of tetrahydro‐3H‐spiro[isobenzofuran‐pyran] derivatives in good yields and selectivity by the condensation of 3‐[2‐(hydroxymethyl)phenyl]but‐3‐en‐1‐ols with aldehydes or ketones. The reaction proceeds smoothly in the presence of indium(III) trifluoromethanesulfonate (30 mol‐%) in dichloroethane at 80 °C. This is the first report on the synthesis of tetrahydro‐3H‐spiro[isobenzofuran‐pyran] scaffolds through a Prins cascade reaction.

A highly efficient and environmentally benign protocol has been developed for the first time to produce a wide range of biologically active 5-hydroxyindole derivatives using montmorillonite KSF clay as a reusable solid acid catalyst. The use of recyclable clay makes this procedure quite simple, more convenient and cost-effective.

InBr 3 -Catalyzed Three-Component, One-Pot Synthesis of Imidazo[1,2-a]pyridines. -The simple method allows the preparation of various title compounds from both aromatic and aliphatic substrates. -(REDDY*, B. V. S.; REDDY, P. S.; REDDY, Y. J.; YADAV, J. S.; Tetrahedron Lett. 52 (2011) 44, 5789-5793, http://dx.